Toxic Epidermal Necrolysis with Some Features of Acute Generalized Exanthematous Pustulosis

Acute generalized exanthematous pustulosis resembling toxic epidermal necrolysis caused by famotidine.

A morbidly obese 60-year-old Hispanic woman with chronic obstructive pulmonary disease, renal failure and asthma but no history of skin disease was hospitalized for a putative urinary tract infection. She had developed a red pruritic painless rash 2 days after starting famotidine. She was allergic to ampicillin and had taken dexamethasone, prozac, percocet, diltiazem, theophylline, ciprofloxaci...

Severe Acute Generalized Exanthematous Pustulosis Induced by Hydroxychloroquine Mimicking Toxic Epidermal Necrolysis

Anti-malarial drugs may induce numerous cutaneous adverse drug reactions as well as exacerbation of psoriasis. Acute generalized exanthematous pustulosis (AGEP) is a clinical reaction pattern that is principally drug induced and is characterized by acute, extensive formation of non-follicular sterile pustules on an erythematous and oedematous substrate. Hydroxychloroquine (HCQ), an anti-malaria...

Acute generalized exanthematous pustulosis simulating Stevens-Johnson syndrome/toxic epidermal necrolysis associated with the use of vismodegib

AGEP: acute generalized exanthematous pustulosis BCC: basal cell carcinoma SJS/TEN: Stevens-Johnson syndrome/toxic epidermal necrolysis INTRODUCTION Basal cell carcinoma (BCC) is a common skin neoplasm that usually has a nonaggressive behavior typically managed with local treatment (eg, surgery, photodynamic treatment, topical agents, or radiation). In some cases, BCC has a much more invasive b...

Acute generalised exanthematous pustulosis and toxic epidermal necrolysis induced by carbamazepine.

Acute generalised exanthematous pustulosis and Stevens-Johnson syndrome (toxic epidermal necrolysis spectrum of severe cutaneous drug reactions) are believed to have distinct underlying pathophysiologies. Our patient, a 28-year-old Chinese woman, represents the first known reported case of clinically-consistent and histologically-proven acute generalised exanthematous pustulosis and toxic epide...

Acute generalized exanthematous pustulosis